The stamp art features a detailed portrait of Wu wearing a black-and-white high-collared traditional Chinese gown known as qipao. The illustration was first drawn in graphite, then rendered in egg tempera paint. The background was painted with the pigment lapis lazuli, a highly valued color historically used in artistic depictions of angels, nobility and religious figures.

The spelling of Wu’s name on the stamp reflects how she wrote her own name and referred to herself. It is also how she was known to the scientific community at large. This Romanized spelling of her name is based on the Wade-Giles system, which is all but obsolete for Chinese words and names. The Pinyin system of phonetic notation for Chinese characters is now the standard in both China and the United States.

Art director Ethel Kessler designed the stamp with original art by Kam Mak.

The Chien-Shiung Wu stamp is being issued as a Forever stamp in panes of 20. These Forever stamps will always be equal in value to the current First-Class Mail 1-ounce price.